New studies on intermittent fasting suggest we can manipulate the immune system simply by changing how much we eat, according to researchers. (via commonhealth)
“They have less pain," says Dr. Vassiliki Boussiotis, a professor of medicine at Beth Israel Deaconess Medical Center."The symptoms of the disease are more controlled.”
In all the studies, researchers had mice either eat less food or go on a water-only fast for roughly a day. Two of the studies looked at T cells and B cells, which are involved in creating immunity against past infections and identifying and destroying pathogens. When the mice in these studies began fasting, Belkaid says, T and B cells vanished from the bloodstream and organ tissues.When the researchers looked in the mice, they found these immune cells hiding inside the bone marrow. “They were able to take shelter there and be protected,” Belkaid says.
“It’s a striking enhancement,” Belkaid says. “The goal is to [eventually] understand this magic soup in the bone marrow and extract what’s making that response. If we can train our cells to do these things, we can have an extraordinary impact on human health.”“This cell in particular is really good at inducing inflammation,” says Dr. Miriam Merad, the study's author and an immunologist at the Icahn School of Medicine at Mount Sinai.
That had important consequences for mice that had multiple sclerosis-like symptoms in Merad’s experiment. With fewer monocytes circulating through the body, she says, overall inflammation went down in these mice, and they started looking healthier. “Now we know a mechanism through which this can be beneficial for patients with these diseases,” she says. “Perhaps patients with immune diseases can go under starvation for some days or change their diet so that they have less nutrients and reduce their inflammation.”
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