The latest drugs for CLL offer prolonged remission, along with a need for better tools to gauge their effectiveness: measurable residual disease could be useful. CLLSM OncTwitter
The latest therapies for chronic lymphocytic leukemia offer prolonged remission, along with a need for better tools to gauge their effectiveness. Data from a demonstrate that assessing measurable residual disease helps doctors evaluate and implement novel treatments.
The review study defined MRD according to the detectable proportion of residual CLL cells. The advantages and disadvantages of different MRD assays were analyzed. Multiparameter flow cytometry, an older technology, proved less sensitive to newer tests. It is reliable measuring to a sensitivity of U-MRD4 and more widely available than next-generation real-time quantitative polymerase chain reaction tests .
The study also demonstrated how MRD can offer more in-depth insights into the success of treatments versus PFS. In the , which compared venetoclax-rituximab treatment with standard chemoimmunotherapy to treat relapsed or refractory CLL, the PFS and overall survival remained significantly prolonged in the VR group at 5 years after therapy.
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