This week in Nature: Stops making sense. Browse the full issue here:
When genes are read by ribosomes, stop codons act as punctuation, telling the ribosome when to halt protein synthesis. But in some protozoa, the base sequences that comprise stop codons can also encode amino acids, depending on where in the messenger RNA the codon appears. In this week’s issue,
reveal how these organisms recognize when codons should be read as an instruction to code and when as an order to stop. The researchers focused on a previously undescribed unicellular parasite called. They found that it has fundamental changes associated with the transfer RNA molecules that allow the ribosome to read stop codons as amino acids and so produce full-length proteins.
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