SGLT2 inhibitor dapagliflozin — despite the cost of the drug being high — is still a cost-effective option compared with standard of care for patients with CKD, at least within the UK, Germany, and Spain, a new analysis shows. MedTwitter
"Results were consistent across the UK, German, and Spanish healthcare settings and important patient subgroups, and they were primarily driven by attenuating disease progression, thereby delaying initiation of dialysis andand reducing rates of hospitalization for health failure and death," the authors conclude.
On the other hand, healthier patients are likely to benefit the most from SGLT2 inhibitor therapy, the editorialists emphasize, prompting them to suggest that policymakers might consider negotiating prices more aggressively for these drugs in order to offset any economic incentive to avoid covering them for younger, healthier patients.
"This study provides a potential blueprint for how the United States could improve affordability of the SGLT2 inhibitors," they point out."The Inflation Reduction Act of 2022...grants Medicare an unprecedented ability to negotiate prescription drug pricing starting in 2026.
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