By crossing into the retina, a new DHA supplement achieves what previous ones could not. For the first time, researchers have developed a form of the omega-3 fatty acid docosahexaenoic acid (DHA) that is capable of crossing into the eye’s retina to ward off visual declines related to Alzheimer’s
Researchers have developed a new form of omega-3 fatty acid docosahexaenoic acid that can cross into the eye’s retina, potentially helping to prevent visual decline linked to Alzheimer’s disease, diabetes, and other disorders. The newly created lysophospholipid form of DHA was found to be more effective than the typical triacylglycerol DHA in fish oil capsules, which cannot reach the eyes.
Sugasini Dhavamani, PhD, research assistant professor in the Department of Medicine at the University of Illinois at Chicago. Credit: Sugasini Dhavamani, University of Illinois at Chicago In healthy eyes, DHA is concentrated in the retina, where it helps maintain photoreceptors, the cells that convert light into signals that are sent to the brain. DHA deficiency in the retina is associated with vision loss. People with Alzheimer’s disease, as well as those with diabetes, retinitis pigmentosa, age-related macular degeneration and peroxisomal disorders, frequently have abnormally low levels of retinal DHA, and visual impairments are common as a result.
“Increasing the retinal DHA at clinically feasible doses has not been possible until now because of the specificity of the blood-retinal barrier that is incompatible with the specificity of the intestinal barrier,” said Dhavamani. “This study uses the novel approach of dietary LPC-DHA that overcomes both intestinal and blood-retinal barriers and improves retinal function.”
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