A team of researchers at Scripps has uncovered findings that suggest a new potential target for developing drugs to treat alcohol use disorder. People with alcohol use disorder (AUD) experience a never-ending vicious cycle of changes in the brain and behavior. AUD can disrupt communication pathways
Researchers discovered higher than usual levels of the immune signaling molecule interleukin 1β in neurons from the brains of alcohol-dependent mice. Credit: Scripps Research
“These inflammatory changes to the brain could explain some of the risky decision-making and impulsivity we see in people with alcohol use disorder,” says senior author Marisa Roberto, Ph.D., the Schimmel Family Chair of Molecular Medicine and a professor of neuroscience at Scripps Research. “In addition, our findings are incredibly exciting because they suggest a potential way to treat alcohol use disorder with existing anti-inflammatory drugs targeting the IL-1β pathway.
In the new study, Roberto, Varodayan, and their colleagues compared alcohol-dependent mice with animals drinking moderate or no alcohol at all. They discovered that the alcohol-dependent group had about twice as much IL-1β in the medial prefrontal cortex , a part of the brain that plays a role in regulating emotions and behaviors.
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