NFL betting odds, picks, tips: Will 49ers handle early road test?

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NFL betting odds, picks, tips: Will 49ers handle early road test?
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Our NFL betting experts offer their best tips and picks for Week 1's Sunday slate of game.

Note: Lines are from Caesars Sportsbook unless otherwise indicated.

How do you approach Week 1? Are there certain strategies you use or types of wagers you gravitate towards or avoid entirely? Do you treat it any differently than any other week?I typically focus on underdogs for Week 1. A trend that stands out to me is divisional home underdogs winning outright 88% of the time since 2012. There are four games on the slate this week where we see this.

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