Three years after then-President Donald Trump pressured NIH to suspend a research grant to a U.S. group studying bat coronaviruses with partners in China, the agency has restarted the award.
in August 2022 that because WIV had not responded to requests to turn over lab notebooks and electronic records, it had terminated the subaward to WIV. But the agency also said EcoHealth could renegotiate the grant without WIV. As discussions continued, in January a
EcoHealth staff will use computers to analyze the viral genomes for risky features, then partner with a previous collaborator, Linfa Wang’s lab at Duke-NUS Medical School in Singapore, to test whether the viruses’ spike proteins can bind to the human angiotensin-converting enzyme 2 receptor, which SARS-CoV-2 uses to enter human cells. Wang’s lab will also study “pseudoviruses” that combine a wild coronavirus with a completely different virus that can’t cause human disease.
NIH is also imposing new requirements on all of EcoHealth’s NIH grants, including prior approval for spending, submission of invoices and timesheets, and a financial audit that EcoHealth must pay for. The nonprofit hasother NIH grants to collect bat and human samples in South and Southeast Asia, including one that proposes chimera work. But Daszak notes that work would only move forward if it passes the special GOF review.
But both he and Perlman say if viruses with the potential to spill over into humans are identified, it will be important to study the live pathogens in high-containment, biosafety level-3 conditions. Although not GOF research, some scientists have argued that even studying natural wild viruses imposes unacceptable risks of a lab escape and should be curtailed. Anthony, however, says “cutting out work with live natural viruses would be tremendously detrimental.
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