Biologists discover removing a protein inhibitor restores metabolic balance. UC Irvine biologists found that removing the SAPS3 component in mice allowed them to maintain a normal energy balance despite consuming a high-fat diet. This discovery could lead to treatments for obesity, diabetes, and
University of California, Irvine biologists have discovered that by eliminating the SAPS3 component of the AMPK protein complex, mice were able to maintain a normal energy balance even when consuming a high-fat diet. This finding, published in Nature Communications, reveals the potential for developing molecules that inhibit SAPS3 to help restore metabolic balance and combat metabolic disorders like obesity, diabetes, and fatty liver disease.
The UCI biologists decided to investigate, believing an AMPK component called SAPS3 serves a significant role. They eliminated SAPS3 from the genome of a group of mice and fed them meals with a 45 percent fat content. The results were startling even to the research team. “Removing the SAPS3-inhibiting component freed the AMPK in these mice to activate, allowing them to maintain a normal energy balance despite eating a large amount of fat,” said Mei Kong, professor of molecular biology & biochemistry and the study’s corresponding author. “We were surprised by how well they maintained normal weight, avoiding obesity and development of diabetes.”
The researchers are working on developing molecules that could inhibit SAPS3 and restore the metabolism’s balance. They plan to next study SAPS3’s role in other conditions with disturbed metabolic systems, such as cancer and aging.
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