Nature research paper: Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I
Our findings reveal yet another unique aspect of physiology that oocytes have evolved to balance their essential function of beginning life with the requirement for longevity. This raises the question whether complex I deficiency in primordial oocytes can be exploited for other purposes. Some cancers seen in young women are highly treatable; however, their treatment leads to a severe reduction of the ovarian reserve and reduced prospects of motherhood.
. Future studies will show whether repurposing complex I antagonists can improve chemotherapy-related infertility, and thus life quality of young female cancer survivors.Ethical committee permission to work with primordial oocytes from human ovary samples was obtained from the Comité Étic d’Investigació Clínica CEIC-Parc de Salut MAR and Comité Ético de Investigación Clínica–Hospital Clínic de Barcelona with approval number HCB/2018/0497.
Animals used in this study were housed in the Barcelona Biomedical Research Park, accredited by the International Association for Assessment and Accreditation of Laboratory Animal Care. Animal euthanasia was performed by personnel certified by the competent authority and conformed to the guidelines from the European Community Directive 2010/63 EU, transposed into Spanish legislation on RD 53/2013 for the experimental use of animals.
at this stage. For the rest of the experiments, oocytes were stripped of accompanying granulosa cells by treatment with 10 mg mltrypsin in PBS for 1 min, followed by washes in MMR. Removal of granulosa cells was confirmed by Hoechst staining of a small number of oocytes.HeLa cells were obtained from ATCC , authenticated based on morphological inspection and confirmed to be mycoplasma negative. Cells were grown in DMEM supplemented with 1 mM sodium pyruvate and 10% FBS .
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