Oral Estrogen Hormone Therapy’s Troubling Tie to High Blood Pressure — A new study in the journal |
Women over 45 taking estrogen hormone therapy orally are more likely to develop high blood pressure than those using transdermal or vaginal forms, according to a study in thejournal. The study also indicated an increased risk associated with animal-derived estrogen compared to synthetic ones. However, the research was limited to postmenopausal women using estrogen-only hormone therapy.
Oral estrogen was associated with a 14% higher risk of high blood pressure compared to transdermal estrogen creams and a 19% greater risk of high blood pressure compared to vaginal estrogen creams or suppositories. Hormone therapy may be prescribed to relieve symptoms of menopause, in gender-affirming care, and in contraception, and previous studies have found that some hormone therapies may reducerisk in menopausal women under 60 years of age or for whom it has been fewer than 10 years since menopause.
This study involved a large group of over 112,000 women, ages 45 years and older, who filled at least two consecutive prescriptions for estrogen-only hormone therapy, as identified from health administrative data in Alberta, Canada between 2008 and 2019. The main outcome of high blood pressure was identified via health records.
Taking estrogen for a longer period of time or taking a higher dose was associated with greater risk of high blood pressure, the authors noted. According to Kalenga, the study’s findings suggest that if menopausal woman take hormone therapy, there are different types of estrogen that may have lower cardiovascular risks.
Association’s 2020 Statement on Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention
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