Scientists from the Department of Neurology at Rutgers Robert Wood Johnson Medical School have traced a previously observed connection between the gut microbiome, made up of tiny organisms in the digestive system, and multiple sclerosis (MS). Their research, conducted using genetically modified m
Multiple Sclerosis is a chronic autoimmune disease that affects the central nervous system. It is characterized by damage to the myelin, which is the protective sheath that surrounds nerve fibers in the brain and spinal cord. MS causes a wide range of symptoms, including muscle weakness, difficulty with coordination and balance, numbness or tingling in the limbs, chronic pain, fatigue, and difficulty with speech and vision.
“Unhealthy dietary habits such as low fiber and high-fat consumption may have contributed to the steep rise of MS in the US,” said Kouichi Ito, an associate professor of neurology and senior author of the study published inMS is a degenerative condition in which the body’s immune system attacks the protective covering of nerves in the brain, spinal cord, and eyes. According to the National Multiple Sclerosis Society, it affects nearly 1 million adults in the United States.
The Rutgers study, which was led by research associate Sudhir Kumar Yadav, used mice engineered with MS-associated genes to trace the link between alterations in the gut bacteria and an MS-like condition called experimental autoimmune encephalomyelitis . The study team then looked for evidence that the same process occurred in people with MS and found significantly elevated Lcn-2 levels in patients’ stools. This marker correlated with reduced bacterial diversity and increased levels of other markers of intestinal inflammation. Additionally, bacteria that seem to ease inflammatory bowel disease were reduced in MS patients with higher levels of fecal Lcn-2.
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