Science, Space and Technology News 2023
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However, this depiction of proteins, the “workhorses of biology,” doesn’t tell the whole story. Around half of all proteins have stringy, unstructured bits hanging off them, dubbed intrinsically disordered regions, or IDRs. The researchers focused on disordered regions of the human cBAF complex, a multi-component group of proteins in the nucleus that works to open up the densely coiled-upinside cells called chromatin, enabling genes along DNA to be expressed and turned into proteins.
While scientists have shown that condensates perform a myriad of tasks, it was not known if these special liquid droplets had any role in chromatin remodeling, nor whether their specific aminoteamed up to study the effects of different mutations in the ARID1A/B IDRs on the ability of the cBAF protein complex to form condensates and recruit partner proteins needed for gene expression.
Strom is co-lead author along with Ajinkya Patil, a former doctoral student at Harvard Medical School. Strom is a postdoctoral researcher in the lab of co-senior author Clifford Brangwynne, Princeton’s June K.
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