A significant milestone in stem cell research.
Jacob Hanna, a professor at the Molecular Genetics Department at the Weizmann Institute of Science in Israel, however, developed a method that would take back such stem cells to a previous step, where they are more "naive". In a, Hanna and his team demonstrated that their technology could make human stem cells so "naive" that they could even be injected into mice, where they would function as if they were mice's own.
In separate work, Hanna's team also developed a special incubator that has all the necessary conditions for the growth of an embryo. In 2021, a group of researchers grew 250 mouse embryos into fetuses with fully formed organs inside this artificial womb. What Hanna and his team wanted to know was if the incubator could also grow embryos that were sourced from stem cells.The researchers then used naive stem cells that had been cultured for years in a petri dish in the lab.
The cells were once again mixed together in the incubator and allowed to grow. While most failed to develop properly, 0.5 percent, or 50 of 10,000 cells, went on to become spheres, which then took the elongated form of embryos.The researchers had labeled each group of cells differently, so they could the growth of the placenta and yolk sac outside the embryo. At day 8.
Apart from helping reduce the use of animals in stem cell research, the techniques developed in his lab could one day also help become a reliable source of cells, tissues, and organs for transplantation.In vitro cultured stem cells with distinct developmental capacities can contribute to embryonic or extra-embryonic tissues after microinjection into pre-implantation mammalian embryos.
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