It is assumed that defective epithelial barriers 'play a role in triggering the onset of two billion chronic illnesses.'
Cezmi Akdis, UZH professor of experimental allergology and immunology and the director of SIAF, noticed that in many, there's no additional wash cycle that removes the remaining rinse agent. Now in a commercial dishwasher, hot water and detergent circulate for around 60 seconds at high pressure.
According to Akdis, these findings have significant implications for public health. "The effect that we found could mark the beginning of the destruction of the gut's epithelial layer and trigger the onset of many chronic diseases," Akdis said. "It is important to inform the public about this risk since alcohol ethoxylates seem to be commonly used in commercial dishwashers," he added.
Methods: We sought to investigate the effects of professional and household dishwashers and rinse agents on cytotoxicity, barrier function, transcriptome, and protein expression in gastrointestinal epithelial cells. Enterocytic liquid-liquid interfaces were established on permeable supports, and direct cellular cytotoxicity, transepithelial electrical resistance, paracellular flux, immunofluorescence staining, RNA-sequencing transcriptome, and targeted proteomics were performed.
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