By genetically testing nearly one thousand embryos, scientists have provided the most detailed analysis of embryo fate following human in vitro fertilization.
Nearly half the embryos studied underwent developmental arrest because of genetic mishaps in early development -- a revealing insight that suggests more IVF babies could come to term with changes in the fertility treatment process. The unique combination of data from arrested embryos also sheds new light on the still largely mysterious earliest stages of pregnancy through natural means.
The findings reveal how some embryos start growing properly while the maternal genetic material pre-loaded into the egg control cell division, only to falter and stall when the embryo's genes take over.Human cells typically receive 46 chromosomes, 23 from each parent. The team discovered nonviable embryos started with the 46-chromosome set, but then passed down incorrect numbers of chromosomes as cells divided.
"Aneuploidy is an example of an extremely strong type of natural selection that's going on every generation in humans," McCoy said."It might just be a feature of human reproduction and development, but it has implications for IVF. So in the long term, we hope that we can improve genetic testing and improve IVF outcomes."
Other study authors include , Abeo McCollin, Kamal Ahuja, and Alan H. Handyside of London Women's Clinic and University of Kent, as well as Christian S. Ottolini, of The Evewell and University College London.Rajiv C. McCoy, Michael C. Summers, Abeo McCollin, Christian S. Ottolini, Kamal Ahuja, Alan H. Handyside.Gastrulation, the process where an embryo reorganizes itself from a hollow sphere into a multilayered structure, is considered a 'black box' of human development.
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