Osteoarthritis (OA) is the most common form of arthritis and is among the top 10 conditions contributing to Years Lived with Disability—a measure reflecting the impact an illness has on quality of life before it resolves or leads to death. To date, no treatments are approved that slow disease progression.
Treatment development has been frustrating in part because animal models of disease caused by joint trauma poorly reflect human disease which usually occurs over many years and without preceding trauma. Researchers from Boston University Chobanian & Avedisian School of Medicine now suggest studying persons after they sustain knee trauma such as anterior cruciate ligament tears .
While most patients recover after sustaining a major joint injury like an ACL tear, a few experience persistent pain and develop OA. Felson suggests that sufficient numbers of such patients exist and could be identified in advance to form a high-risk group in which treatments to prevent disease could be tested.
By using the MOON risk factors -- incorporating pain and structural changes in all joint tissues, especially cartilage loss -- to select persons at high risk of later pain, they could assemble a cohort at high risk of substantial post ACLR pain.
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