According to a new study, substances that are said to boost athletic performance can also activate a receptor that speeds up the development of pancreatic cancer in mice. The progression of precancerous pancreatic lesions into pancreatic cancer is fueled by a cell nuclear receptor that is activat
A recent study has linked high-fat diets and increased risk of pancreatic cancer.
Pre-cancerous pancreatic lesions in mice that are similar to those found in people contained greater levels of the transcriptional receptor peroxisome proliferator-activated receptor-delta , according to research conducted by Imad Shureiqi, M.D. The research was published in the journalMicroscopic pictures of pancreatic tissue in mice.
Activation of PPARδ correlates with excessive exposure to certain ligands, both natural and synthetic. Some ligands naturally occur in high-fat diets, which have been associated with increased risk for pancreatic cancer in humans and animal models. High-fat diets are enriched with fatty acids that are natural ligands of PPARδ.
Shureiqi explains that, initially, researchers found that these synthetic ligands reduced fatigue in mice. This news made its way to major media outlets, who nicknamed it “exercise in a pill.” “Unfortunately, what the media didn’t address was the dark side of PPARδ. Like muscle cells, synthetic PPARδ ligands also help cancer cells get more energy from fats as a fuel source,” he said.
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