Scientists have created mice with two biologically male parents for the first time — a significant milestone in reproductive biology.
The team, led by Katsuhiko Hayashi, a professor of genome biology at Osaka University in Japan, generated eggs from the skin cells of male mice that, when implanted in female mice, went on to produce healthy pups, according to research published March 15 in the peer-reviewed journal Nature.
Hayashi said this low success rate — around 1% — wasn’t down to the process of sex chromosome conversion but the reality that cells cultured in a lab are typically inferior to those in a living animal. “This is due to the suboptimal condition of the culture system. Especially, if the culture period is long , then the cell potential is compromised,” Hayashi said via email.
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