Scientists determine structure of a DNAdamage 'first responder' sloan_kettering NatureSMB NatureSMB
What's not captured by this analogy is the fact that our DNA requires constant upkeep to maintain its integrity. Were it not for dedicated DNA repair machinery that routinely fixes mistakes, the information within DNA would be rapidly degraded.
"We know that this attachment is a pivotal step necessary for initiating an effective repair program," says Dirk Remus, aat the Sloan Kettering Institute who studies the fundamentals of DNA replication and repair."But the mechanisms involved are completely obscure." Dr. Remus realized that if these complexes could be viewed at atomic resolution, they would provide a set of freeze-frame images of the individual steps in the repair process. That's when he turned to Dr. Hite's lab for help.to figure out how it works?' And that's what he did."electron microscopy
"When Rich first produced the structure, I thought he got it wrong because it was against all the expectations," Dr. Remus adds."Now, in hindsight, it all makes perfect sense."The 9-1-1 clamp is shaped like a ring. To carry out its function, it needs to surround the broken DNA at the junction between an exposed end of one strand of a double-stranded piece of DNA abutting a single-stranded one.
México Últimas Noticias, México Titulares
Similar News:También puedes leer noticias similares a ésta que hemos recopilado de otras fuentes de noticias.
DNA cold cases: 47-year-old Elk man arrested for home invasions, rapesAccording to a release from Pullman police, evidence collected when the crimes occurred matched DNA profiles that were found through familial genealogy sources, which investigators linked to Kenneth Downing.
Leer más »
Ancient DNA could help California tribe get federal recognitionResearchers have used DNA from two archaeological excavations to identify the Ohlone’s genetic signature and link ancient individuals—some buried nearly 2000 years ago—to their modern-day descendants.
Leer más »
33 Sets Of Celebs Who Are Related By Blood That Genuinly Surprise Me Even Though Half Of Hollywood Shares The Same DNAMoral of the story is everyone in Hollywood is related.
Leer más »
500+ Academics Call for End to Climate Research Funded by Fossil Fuel Industry'Our universities must be climate leaders, not climate laggards,' said climate scientist Peter Kalmus ClimateHuman
Leer más »
The First-Ever Evidence of the MultiverseScientists determined that the 'Cold Spot' isn't caused by a lack of galaxies, but may have been caused by our universe bumping into another universe.
Leer más »