“For the first time we get a clue to how and why neurons die in Alzheimer’s disease. There’s been a lot of speculation for 30-40 years, but nobody has been able to pinpoint the me…
Tau is a protein that “forms insoluble filaments that accumulate as neurofibrillary tangles in Alzheimer’s disease and related tauopathies,”The research found that the disease progresses through necroptosis – a form of cellular suicide– caused by tangles of tau.The researchers from Belgium and the UK now believe that the abnormal amyloid begins to build up in the spaces between the neurons causing brain inflammation which results in a change to the internal chemistry.
As the tangles of tau accumulate, the brain cells begin producing MEG3 molecules, which trigger necroptosis. Once the researchers understood this development, they were able to assist the brain cells’ survival by blocking the MEG3.Once the researchers understood this development, they were able to assist the brain cells’ survival by blocking the MEG3.but will likely take years to be implemented into medicine.
Tara Spires-Jones, from the University of Edinburgh and the president of the British Neuroscience Association, told the BBC that this research “addresses one of the fundamental gaps in Alzheimer’s research” and noted that “these are fascinating results and will be important for the field moving forward.”
But clarified that “many steps are needed” until this work can help people diagnosed with the progressive disease.
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