The research team combined data from 18 studies conducted in the U.S., Europe, and Australia.
However, the study found that some genes that are currently included on genetic test panels are not linked to aggressive disease, while some genes that are not on the panels are associated with a higher risk for more severe, fatal prostate cancer.
The corresponding author, Christopher Haiman, ScD, who holds the AFLAC Chair in Cancer Research and is a professor of Population and Public Health Sciences at the Keck School of Medicine, emphasized the necessity for extensive studies to guide the development of gene panels for testing. He pointed out that certain genes included in these panels had origins in smaller studies and did not exhibit a significant association with prostate cancer in their research.
Furthermore, their findings suggested the potential inclusion of other genes. Although the results lacked absolute certainty, it was evident that further research was required to identify the specific genes that oncologists should prioritize for testing.The research team combined data from 18 studies conducted in the U.S., Europe, and Australia, and compared the frequency of mutations among two groups of prostateHaiman and his colleagues conducted their investigations in two stages.
The eleven genes that emerged as having mutations significantly linked to aggressive prostate cancer include BRCA2, which is also known for its connection to breast cancer. The list of genes, as well as those currently screened in genetic tests found not to be linked to serious disease, could influence individualized treatment for prostate cancer, as well as screening.
Haiman explains that some patients who had less aggressive diseases also had the same mutations as those who had more advanced diseases. He says that this could mean that these patients have a higher chance of their cancer becoming worse over time. He suggests that screening should be not only target men with advanced disease or family history but also for those who have these genetic variants.
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