The research team used a new CRISPR-based genome editing system named PESpRY.
that is exceptionally adaptable and could potentially remedy numerous genetic mutations responsible for causing different diseases.in mice affected by genetic disorders such as Leber congenital amaurosis affecting the retinal pigment epithelium, a non-neuronal cell layer in the eye that supports the light-sensing rod and cone photoreceptor cells.
“The ability to edit the genome of neural retinal cells, particularly unhealthy or dying photoreceptors, would provide much more convincing evidence for the potential applications of these genome-editing tools in treating diseases such as retinitis pigmentosa,” says Kai Yao, a professor at the Wuhan University of Science and Technology.Qin et al.Retinitis pigmentosa is estimated to affect one in 4,000 people and can result from mutations in more than 100 different genes.
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