Scientists have discovered two genes that may trigger Raynaud's phenomenon, a condition that can cause fingers and toes to go cold and numb because of the constriction of tiny blood vessels under the skin.
“We identify two distinct genes that point to two distinct mechanisms,” lead researcher Maik Pietzner, chair in health data modeling at Queen Mary University of London's Precision Healthcare University Research Institute, toldPeople may not be able to move their hands well during an attack, Dr. Marie Gerhard-Herman, an associate professor at Harvard Medical School in Boston, toldAlthough typically treated with lifestyle changes, certain medications can help.
“About half the people who have primary Raynaud's phenomenon have another first-degree relative who also has Raynaud's,” said Hummers, who co-directs John HopkinsThe study included UK Biobank data from more than 440,000 people. Researchers found more than 5,000 cases of Raynaud's. About 68% were primary Raynaud's cases.
The scientists found that one gene variant affects how blood vessels narrow. Those with the variant had a higher number of a particular receptor for hormones that are released under“The genetic studies that have been done in Raynaud's up until this point hadn't been as compelling as this one,” Hummers said. “It's a huge step forward.
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Scientists Spot Genes Linked to Raynaud's PhenomenonScientists have discovered two genes that may trigger Raynaud's phenomenon, a condition that can cause fingers and toes to go cold and numb because of the constriction of tiny blood vessels under the skin. 'We identify two distinct genes that point to two distinct...
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