GlaxoSmithKline and AstraZeneca both reported trial results that will likely mak...
BARCELONA - GlaxoSmithKline and AstraZeneca both reported trial results that will likely make their competing drugs available to a wider group of ovarian cancer patients, possibly helping GSK catch its rival in a highly contested drug class.
AstraZeneca and its U.S. development partner Merck & Co said their Lynparza drug cut the risk of the cancer progressing again by 41%. The figure was 38% for GSK’s drug. While the Lynparza trial worked on the assumption that patients get an initial treatment of chemotherapy plus Roche’s Avastin, the trial with GSK’s Zejula included only patients who had initially gone through chemotherapy only.
Many cancer cells have a limited ability to make DNA repairs during cell division, as healthy cells would. This feature makes tumors genetically volatile and helps them develop resistance to treatment over time.
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