Adjuvant endocrine therapy for early breastcancer is associated with sexual dysfunction, particularly in women who have had a mastectomy and in women with physical and endocrine disorder symptoms. bcsm
, and ovarian function suppression or ablation, can lead to vaginal dryness, dyspareunia, trouble reaching climax, and loss of libido. Plus, radiation can adversely affect response to sensation., can lead to sexual dysfunction.
Patient-reported outcomes across a broad range of symptoms common during endocrine therapy at 3, 6, 12, 24, 36, 48, and 60 months were completed by participants. Sexual function was evaluated by the Medical Outcomes Study Sexual Problems measure. Patients were excluded if they had incomplete MOS-SP scores or had baseline MOS-SP scores greater than 92. Of the 300 participants, the mean age was 62 years, and 84.3% had stage I-II breast cancer.
Among treatments initiated, 55% received an AI only, 39.7% received tamoxifen only, 5% received tamoxifen plus ovarian function suppression , and one patient received an AI plus OFS. Five patients switched between types of their endocrine therapy and the remainder did not switch.
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