Nature research paper: Tbx2 is a master regulator of inner versus outer hair cell differentiation
newborn pups were treated with tamoxifen at P0 and collected for examination at each subsequent day from P1 to P8. Immunohistochemistry at P5 reveals that hair cells in the position of the IHCs express the IHC functional marker VGLUT3 , but also the OHC functional markers Prestin and PMCA2 . In , former IHCs are identified by the expression of TdTomato. Hence, at this time transdifferentiating hair cells display features of both IHCs and OHCs.
Extended Data Fig. 5 Schematic illustration of the various forms of transdifferentiation between IHCs and OHCs. IHCs and OHCs are depicted from their onset after proliferation of progenitors has ceased , through embryonic and postnatal stages, and into their adult form. As differentiation proceeds, hair cells acquire increasing numbers of characteristic markers . The course of normal development is indicated with black arrows. IHCs express TBX2 from their onset and throughout life. OHCs express INSM1 and BCL11b transiently during embryonic and early postnatal stages.
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