Metabolomics analyses reported an increased risk of Cardiovascular Disease associated with the ArtificialSweetener Erythritol, supported by mechanistic studies showing that high levels of erythritol enhanced platelet reactivity & Thrombosis formation.
). With the column matrix and mobile phase /gradient employed, coupled with the characteristic parent [M+NH] —> daughter ion transition used , baseline chromatographic resolution of the two structural isomers was achieved.
Erythritol levels in patients stratified by presence of MACE or CAD. Data are shown as log of plasma Erythritol. Plotted are individual values as dots. Boxes represent interquartile ranges with the notch indicating the median. Lower whiskers represent smallest observation and upper whiskers largest observation . Two-sided P values were calculated by Mann–Whitney U-test. Numbers of subjects within each group are indicated.
ADP-stimulated and Thrombin receptor-activating peptide6-stimulated platelet aggregometry responses of human platelet-rich plasma with fixed concentration of erythritol versus normal saline . Data in bar graphs are represented as means , and two-sided P values were calculated by Mann Whitney Test and by 2-way analysis of variance with Sidák’s post hoc test. Sidák’s adjusted P values for Erythritol 45 μM vs. vehicle: for ADP 2 μM P=0.01, ADP 3 μM P=0.005, for erythritol 90 μM vs.
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