Our bodies are pretty ingenious when it comes to self-repair, and scientists have been studying in detail the ways in which the heart patches itself up after a heart attack (myocardial infarction). They hope to find clues that could lead to better tr
are crucial in the way that the heart repairs itself after a heart attack has caused damage to the heart muscle., specialist cells that can destroy bacteria or initiate helpful inflammation responses. As the first responders on a scene after a heart attack, these macrophages produce a particular type of protein called VEGFC, the researchers report.
"We found that macrophages, or immune cells that rush to the heart after a heart attack to 'eat' damaged or dead tissue, also induce vascular endothelial growth factor C that triggers the formation of new lymphatic vessels and promotes healing,"it as a Jekyll and Hyde scenario: 'good' macrophages producing VEGFC and 'bad' macrophages not producing any VEGFC but causing a pro-inflammatory response that can cause further harm to the heart and surrounding tissue.
In order for the heart to fully repair itself, dying cells need to be cleared away – a process known as efferocytosis that macrophages play an important role in. Studying this process in cells in the lab and in mice, the team pinpointed the way that the right type of VEGFC-producing macrophages did a proper repair job.
What future research could look into next is how to increase the number of helpful macrophages in the heart and reduce the number of – or even eliminate – the damaging macrophages, boosting the chances of a healthy recovery. "Our challenge now is to find a way either to administer VEGFC or to coax these macrophages to induce more VEGFC, in order to speed the heart repair process,"
México Últimas Noticias, México Titulares
Similar News:También puedes leer noticias similares a ésta que hemos recopilado de otras fuentes de noticias.
An Essay Concerning Humane Understanding, Volume I: ESSAY CONCERNING HUMAN UNDERSTANDING | HackerNoon
Leer más »
Proteins in human bones near Pompeii survived temperatures of 500°CWhen Mount Vesuvius erupted in AD 79, the nearby town of Herculaneum was buried in extremely hot ash, and flooding may have preserved the proteins in human bones found there
Leer más »
Human genome of Pompeii victim sequenced for the first timePompeii is one of the world's most intensively studied archaeological sites, but getting detailed genetic information from the skeletal remains preserved in Pompeii had long eluded scientists.
Leer más »
Human genome of Pompeii victim sequenced for the first timePompeii is one of the world's most intensively studied archaeological sites, but getting detailed genetic information from the skeletal remains preserved in Pompeii had long eluded scientists.
Leer más »
'Brazen disregard for human life,' Houston man sentenced to life for killing Spring coupleKhari Ty Kendrick, 28, was convicted for the execution-style shooting of a couple in their home. “A sentence of life in prison without parole is justice for such a random attack and brazen disregard for human life,' DA Kim Ogg said.
Leer más »