🔄FROM THE ARCHIVE: New advances in stem cell technology are paving the way for same-sex couples to have a baby that’s entirely their own.
Cara Gormally’s pregnancy was shadowed by grief. As a queer woman wanting to have a baby, the biology professor had figured finding a sperm donor would be the only obstacle she and her partner faced. But thanks to Gormally’s organizational skills and love of making lists, the couple landed on a donor with relative ease.“So much of the process depended on random, heart-breaking chance,” she says. The emotional and financial roller coaster was exhausting.
Gormally and other same-sex partners are currently barred from their dreams by a phenomenon called genomic imprinting. It uses a distinct tag from each parent to mark the DNA that mammals pass on to their offspring. The process ensures that, for a small percentage of genes, we only express the copy of genetic material provided by our mother or our father. When this imprinting process goes awry, kids can end up with inactive gene regions that cause miscarriages, developmental defects and cancer.
Later experiments revealed mice developed differently depending on whether they happened to receive both copies of certain regions of DNA from one parent . But the scientists had to clear a few more hurdles to generate mice with two genetic fathers. They found, through a process of trial and error, that they needed to remove twice as many imprinted regions in the bipaternal mice as the bimaternal mice. In total, the team deleted seven imprinted regions to successfully create mice from two dads.
“It does not mean that they are normal in every aspect,” Li cautions. “One cannot investigate all the aspects under restricted experimental conditions with a limited number of animals.”
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