TMS is associated with both anxiolytic and antidepressant effects in patients with anxious depression, new research suggests.
Aaronson, who is also an adjunct professor at the University of Maryland School of Medicine, Baltimore, noted that between 50% and 75% of patients with depression also have significant anxiety symptoms.
Aaronson noted that previously reported outcomes from TMS for anxious depression have been"suggestive of efficacy but have not been well studied within a large cohort." In the current study, researchers retrospectively analyzed data on 1820 patients with MDD. All had completed the Patient Health Questinonaire-9 and the Generalized Anxiety Disorder-7 at baseline and following at least one TMS intervention.
However, the anxious group was significantly younger compared with the nonanxious group. They also reported higher severity of depressive symptoms at baseline, with PHQ-9 scores approximately 2.5 points higher. "Anxiolytic and antidepressant effects were consistent across the ITT and Completed samples and patients who received any TMS protocol or only HF-LUL TMS," the investigators reported.
However, response and remission rates were significantly higher in the nonanxious vs the anxious group.
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