Trans-segmental imaging in the spinal cord of behaving mice
Spine-mounted macroscopes of <10 g and low center of gravity have little effect on mouse linear treadmill behavior. Example videos showing the same mouse on a linear treadmill with and without the wearable macroscope. The mouse was habituated to carrying the microscope for 5 d before testing. The videos were recorded at 200 fps but are replayed at reduced speed to allow comparison of mouse gait.
Stable trans-segmental imaging of microglial cell bodies and processes in focally restrained behaving CX3CR1–GFP mice. Top left, example behavior videos from a pinch and run trial of a 12-week-old female CX3CR1–GFP mouse focally restrained on a spherical treadmill. Bottom, simultaneously acquired time-lapse recording showing GFP-labeled spinal microglia across a 2.25 mm × 0.98 mm FOV. The data were obtained at a focal depth of ~50 μm below the pia. Elapsed time is indicated.
High-speed trans-segmental imaging of microglia calcium activity in freely behaving CX3CR1-GCaMP5g-tdTomato mice. Top left, example behavior videos showing four different trial types in a 16-week-old male CX3CR1-GCaMP5g-tdTomato mouse with a mounted wearable macroscope exploring an open field arena. Note that the mouse could carry the device on its back without extensive training . It had not seen the arena before. The shown data were acquired over a ~105-min period after macroscope mounting.
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