In 2001 the sequencing of the human genome revealed a surprising fact: over 45% of our genome comes from sequences called transposons, 'jumping' genes that can move within the genome, generating new copies of themselves through molecular mechanisms of cut-and-paste or copy-and-paste.
In 2001 the sequencing of the human genome revealed a surprising fact: over 45% of our genome comes from sequences called transposons,"jumping" genes that can move within the genome, generating new copies of themselves through molecular mechanisms of cut-and-paste or copy-and-paste.
, shows that the RNA produced by LINE transposons is essential for the development of the cerebral cortex in mice. Without this RNA, the cerebral cortex does not develop correctly, and the proportion of the different cell types that make up this organ is compromised. The key discovery is that LINE elements are recognized by protein complexes that initiate transcription processes essential for proper embryonic development.
The data analysis also identified a group of genes containing LINE copies that, when activated, suppress the transcription of the host genes, suggesting that these sequences contain specific signals recognized by cell regulatory mechanisms.
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