A quarter of the world's population has latent tuberculosis. Only 10% go on to develop symptoms
reckons, roughly a third of new cases in 2018 went undiagnosed. That is partly because the most widely employed diagnostic method today remains the one Koch himself used: examining a patient’s sputum under a microscope to look for telltale bacteria. This procedure, which Barry Bloom of Harvard University, a doyen of the field, calls “an embarrassment to science”, detects only about half of activecases.
on the market. Who would pay for these is an important question, for the $500m price tag involved is commercially unattractive. The firm says it is in discussions with outside organisations about the matter, and that saying anything more at this stage would “compromise” progress. Observers worry, though, that delay will mean the stockpile of vaccine available for trials will expire—and that creating more will add to costs.
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