Two genetically modified pig hearts were just successfully transplanted into humans, in what is the second major move forward for pig-human heart xenotransplantation this year.
"We don't really know why that heart failed and why he died," Montgomery said. That, he argues, is why it's important to continue doing research on deceased donors, before moving forward with more live xenotransplantation trials."This is a huge, huge step in the right direction," Dr. Chris Colbert, an ER doctor from Chicago, who was not involved in the research, told Insider after hearing the news."It's not just an organ, but an organ match.
The two pig hearts transplanted at NYU this summer were able to function for at least 72 hours inside human bodies because they were engineered with 10 genetic modifications. Four of the gene edits were porcine, to prevent transplant rejection and abnormal growth, and six were human transgenes, designed to make human and pig parts more compatible.
"It really is the next frontier in transplant medicine," Dr. Preethi Pirlamarla, a heart transplant cardiologist at Mount Sinai in New York, who was not involved in the NYU research, told Insider."It's really just a modern miracle that we're even able to consider this.
But, she also said she wouldn't be surprised if pig-to-human heart transplants became commonplace within her career. "Do I see it happening in the next year? I don't think so," she said."Do I see it coming down the line 5, 10 years? I think it is very possible."
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