Understanding how cancercells migrate paves the way for targeted therapies NUSingapore
Schematic showing the interactions between BPGAP1 and GTPases Rac1 and RhoA .
Being a complicated and multistep process, effective treatment options for metastasis are limited and cater more towards symptom relief at advanced stages than eliminating root causes. Unraveling the underlying mechanistic action of BPGAP1 may be the key to apprehending the rouge traversal of cancer cells and paving the way to create more directed approaches to cancer intervention.
The mobility of a cell is propelled by changes in its cytoskeletal organization, which in turn is governed by a set of proteins, including a group known as GTPases. GTPase can be described as a molecular switch which activates specific pathways to carry out cellular functions.
While scientists recognize Rac1 and RhoA's involvement in cell movement, Dr. Wong and his team found that another protein, BPGAP1, does not only have interactions with both of them, but is also highly expressed in cancer cells and extensively promotes cell migration. They later revealed that BPGAP1 acts as a scaffold and coordinator between the two GTPases, therefore serving as a key regulator of their activities.
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