Scientists from UCL, MRC LMB, and AstraZeneca have found a compound, named '1938', that boosts nerve regeneration after injury and shields heart tissue from significant damage. The compound, which stimulates the PI3K signaling pathway linked to cell growth, represents a promising avenue for therapie
A research collaboration has discovered a new compound, named ‘1938’, which can promote nerve regeneration after injury and protect cardiac tissue from significant damage, as seen in heart attacks. Published inScientists from UCL, MRC LMB, and AstraZeneca have found a compound, named ‘1938’, that boosts nerve regeneration after injury and shields heart tissue from significant damage.
Phosphoinositide 3-kinase is a type of enzyme that helps to control cell growth. It is active in various situations, such as initiating wound healing, but its functions can also be hijacked by cancer cells to allow them to proliferate. As a result, cancer drugs have been developed that inhibit PI3K to restrict tumor growth. But the clinical potential of activating the PI3K pathway remains underexplored.
Researchers at UCL’s Hatter Cardiovascular Institute found that administering 1938 during the first 15 minutes of blood flow restoration following a heart attack provided substantial tissue protection in a preclinical model. Ordinarily, areas of dead tissue form when blood flow is restored which can lead to heart problems later in life.
Given the positive findings, the group is now working to develop new therapies for peripheral nerve damage, such as those sustained in serious hand and arm injuries. They are also exploring whether PI3K activators could be used to help treat damage in the central nervous system, for example, due to spinal cord injury, stroke, or neurodegenerative disease.
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