Venous Thromboembolism: Nonvitamin K Oral Anticoagulants Superior in Real World

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Venous Thromboembolism: Nonvitamin K Oral Anticoagulants Superior in Real World
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Rivaroxaban/apixaban associated with a lower risk of recurrent VTE and major bleeding events compared with SoC.

In patients with venous thromboembolism , rivaroxaban and apixaban were associated with a lower risk of recurrent VTE and major bleeding events compared with the standard of care .Findings support the recent American Society of Haematology recommendations that favour the use of nonvitamin K oral anticoagulants in the management of patients with VTE.

A meta-analysis of 65 real-world studies, identified after a literature search across electronic databases, which compared rivaroxaban or apixaban with SoC in adult patients with deep vein thrombosis and/or pulmonary embolism.Compared with SoC, rivaroxaban and apixaban were associated with a lower risk of recurrent VTE and major bleeding:Rivaroxaban vs SoC was associated with a reduced risk of all-cause mortality (HR 0.56; 95% CI 0.39 to 0.

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