What to know about the drug xylazine and why it's making fentanyl worse

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What to know about the drug xylazine and why it's making fentanyl worse
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The DEA is warning that a powerful veterinary sedative is being combined illicitly with fentanyl, making it even more dangerous.

Users of the mixture can be at higher risk for deadly overdose because unlike fentanyl, xylazine is not an opioid, and so the common opioid overdose treatment naloxone is not known to be effective in reversing its effects, according to the federal government.

A logo reading DEA Special Agent is pictured in the Office of the US Drug Enforcement Administration , May 29, 2019 in New York City.In addition to the risk of increased risk of death posed by xylazine, "people who inject drug mixtures containing xylazine also can develop severe wounds, including necrosis -- the rotting of human tissue -- that may lead to amputation," the DEA said in a statement.

Xylazine is not readily detected by routine toxicology screening, making exposure to the drug difficult to diagnose, according to anto more than 100,000 deaths annually in the U.S., about two-thirds of which are fentanyl-related

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