Drugs like MDMA and psilocybin show promise for treating depression and PTSD, but is there any risk of addiction? critica_life explains.
. Active MDMA was associated with robust improvement in PTSD compared to placebo and the investigators reported few adverse side effects from MDMA.
A psychedelic drug now under study for the treatment of a psychiatric disorder is psilocybin, the active ingredient in “magic mushrooms.” With effects similar to LSD, magic mushrooms have long been used to induce a “trip” that includes hallucinations and euphoria. Nevertheless, last April investigators reported in thethat compared psilocybin to the SSRI antidepressant escitalopram for the treatment of major depression.
It would be helpful if we could say that these drugs are addressing some underlying abnormalities in conditions like depression and PTSD. We do have information about the biological mechanisms of action of all three of them. Ketamine works mainly through an interaction with the brain’s glutamate neurotransmission system and also has effects on
. Both MDMA and psilocybin work mainly through the enhancement of the brain’s serotonin receptor system, the same system that is affected by SSRI-type antidepressants like Prozac and Lexapro.
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