Science, Space and Technology News 2023
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Because ammonium chloride can affect the concentration of acid — that is, hydrogen ions — within a cell, the team wondered if it could somehow trigger OTOP1.To answer this question, they introduced the Otop1 gene into lab-grown human cells so the cells produce the OTOP1 receptor protein. They then exposed the cells to acid or to ammonium chloride and measured the responses.
To confirm that their result was more than a laboratory artifact, they turned to a technique that measures electrical conductivity, simulating how nerves conduct a signal. Using taste bud cells from normal mice and from mice the lab previously genetically engineered toThe popular Scandinavian candy salty licorice contains the alkaline salt ammonium chloride, giving the candy a unique flavor.
“This was really the clincher,” Liman said. “It shows that the OTOP1 channel is essential for the behavioral response to ammonium.”
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