Bivalent vaccines elicit broad immune responses that neutralize ancestral SARS-CoV-2 and variants of concern, and offer a customizable approach to protect from COVID-19 as new virus variants emerge. msdiamondlab
We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.The emergence of SARS-CoV-2 variants in the Omicron lineage has resulted in diminished COVID-19 vaccine efficacy and persistent transmission.
Suzanne M. Scheaffer, Bradley Whitener, Baoling Ying, Chieh-Yu Liang, Larissa B. Thackray & Michael S. DiamondDiana Lee, Kai Wu, Hardik Jani, Philippa Martin, Nicholas J. Amato, Laura E. Avena, Daniela Montes Berrueta, Arshan Nasir, Gwo-Yu Chuang, Guillaume Stewart-Jones, Andrea Carfi, Sayda M. Elbashir & Darin K. EdwardsStephen D. Schmidt, Sijy O’Dell, Richard A. Koup & Nicole A. Doria-RoseMichael S. DiamondMichael S.
The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USACenter for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, Saint Louis, MO, USA
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