New imaging data show distinctive brain changes that appear to explain memory and cognitive problems following Lyme disease. MedTwitter
"We found that the brains of PTLD patients had been altered by the disease — specifically, white matter function increased while performing a cognitive task, which is unusual to observe with the MRI methods we used, and we did not see such activity in the healthy control group," said Marvel.
"We then looked more closely at the white matter in the PTLD group, and we were very surprised to find that axon diffusion — or 'leakage' from the white matter, which is usually considered to be pathological — was associated with"This led us to speculate that white matter changes are a healthy response to Lyme disease's effects on the brain," she said.
Although the sample size was small,"the authors used rigorous methods to diagnose and characterize their patients and used state-of-the-art brain imaging and analysis methods," said Keilp, who heads the neuropsychology laboratory within the Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, and was not involved with the study.
The authors"have shown us a way forward to examine these patients and this disorder in greater detail as we attempt to unlock the uncertainties surrounding the physiological basis of these patients' symptoms," he said. Funding for the study was provided by an anonymous donor. The authors and Keilp report no relevant financial relationships.Batya Swift Yasgur MA, LSW is a freelance writer with a counseling practice in Teaneck, NJ. She is a regular contributor to numerous medical publications, including Medscape and WebMD, and is the author of several consumer-oriented health books as well as Behind the Burqa: Our Lives in Afghanistan and How We Escaped to Freedom .
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