Scientists reanimate dead cells in pigs, a potential breakthrough for organ transplants
Evan BushResearchers at Yale University used a new technology to restore cells in some organs of pigs that had just died, bringing the animals’ cells back to function. The findings, which were published Wednesdaybut also teases new possibilities for the collection of human“My eyes went wide,” Brendan Parent, an assistant professor of bioethics at the NYU Grossman School of Medicine, said about the moment he first read the new findings.
To evaluate how well the new system, called OrganEx, works, the researchers caused heart attacks in pigs that had been anesthetized. The pigs were dead for an hour, and the researchers cooled their bodies and used neural inhibitors to ensure the animals did not regain consciousness during subsequent experiments.
“We can say that animals were not conscious during these moments and we don’t have enough information to speculate why they moved,” Sestan said. The definition of death is a moving target that has shifted as new life-support technology like ventilators or ECMO were developed. Ethicists view OrganEx as ECMO on steroids and something that could change the definition of what medical death means.
Instead, the researchers see more immediate avenues for real-world use for the research. Today, transplant surgeons must scramble to stay ahead of ischemia and prevent organs from going too long without blood supply.
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