More women should be assessed for BRCA mutations, new recommendations say

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More women should be assessed for BRCA mutations, new recommendations say
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More women should be assessed for harmful mutations in the BRCA1 and BRCA2 genes that can increase risk of certain cancers, according to new recommendations.

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Cancer: The facts 01:00Previously, it was recommended for women who have a family history of breast, ovarian, tubal or peritoneal cancer to be assessed for harmful BRCA1 or BRCA2 mutations. That recommendation was last made in 2013 by the US Preventive Services Task Force, a volunteer panel of national experts that makes evidence-based recommendations for the primary care community.

Angelina Jolie reveals double mastectomy 01:47The updated USPSTF recommendation statement clarifies that primary care clinicians should assess women with a personal or family history of breast, ovarian, tubal or peritoneal cancer for possible BRCA1 or BRCA2 mutations, said Dr. Banu Arun, professor of breast medical oncology and co-medical director of the Clinical Cancer Genetics Program at MD Anderson Cancer Center in Houston, who was not involved in the new recommendations.

The prevalence of such a mutation"is estimated to be about 2% for women of Ashkenazi Jewish heritage but only 0.1% in women from other populations. This raises the possibility that a patient for whom comprehensive testing is warranted might be falsely assured by a negative test result and not seek further evaluation, or even that a clinician might wrongly assume that the patient does not require referral," Yung and Korde wrote in the editorial.

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