Scientists monitored rats reaction to stress over a 21-day period to find out what brain mechanisms affected their susceptibility or resilience to anhedonia.
Scientists have identified certain mechanisms in the brain that can trigger a loss of pleasure and interest, and have found a way to reverse the process and boost resiliency—in rats.
Susceptibility to anhedonia varies from person to person, or rat to rat. Previous research looking at animals and depressed patients that have committed suicide suggests this relates to an impaired functioning of the brain reward system.
Researchers used a rat model to identify differences in the brain that might cause some people to be more susceptible to stress-induced anhedonia.Interestingly, researchers were unable to determine which rats were susceptible and resilient to socially-induced stress before—or even during the early stages of—the experiment. This suggests the response was not triggered by acute moments of stress but rather developed over an extended period of time, with chronic exposure to stress.
The partition would be returned to position after three minutes or earlier if the"intruder" rat suffered social defeat—defined as holding a submissive posture for 3 seconds or more as he is pinned down by other males.
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