Rheumatoidarthritis patients are no more likely to have a heart attack if they are treated with an IL-6i than if they are treated with a TNFi, according to data presented here at BSR2023.
April 24, 2023
"This result reassures patients and clinical teams about the long-term treatment effects on myocardial infarction in a real-world setting," said Tian Zixing, a PhD student at the University of Manchester in Manchester, England. The study population consisted of all patients registered in the BSRBR-RA over the past 20 years who had started treatment with one of the many TNFi drugs available in the UK — adalimumab , etanercept , infliximab , certolizumab pegol , and golimumab — or the two available drugs that target the effects of IL-6 — tocilizumab , which targets IL-6 itself, and sarilumab , which targets the IL-6 receptor.
"It is very important to consider the treatment sequence," Tian said."Most patients start first-line treatment with a TNF inhibitor, with only a few patients starting an IL-6 inhibitor," she said."IL-6 inhibitors are more commonly used in the later stages of disease, when more cardiovascular risk factors have accumulated."
There are a lot of strengths to these data, but of course the possibilities of residual confounding and confounding by indication exist, Tian said. There were also missing data that had to be imputed.
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