Researchers find evidence that genes involved in Williams-Beuren syndrome may have helped our faces become more slender.
Humans have domesticated other animals for thousands of years. One of the most notable species is dogs, which were descended from wolves. Previous research has shown the gene BAZ1B was involved in the shift from wolf to dog, with these genetic changes helping to make dogs smaller, with softer faces.
They discovered there were mutations in regions that depend on BAZ1B compared with the Neanderthals and the Denisovan sample. Their research revealed the enrichment of regulatory changes in BAZ1B, providing what they say is the"first empirical validation of the human self-domestication hypothesis," and showing this gene is a"master regulator" of the modern human face.
"[The] researchers have...zeroed around BAZ1B with the potential to elucidate the biological bases for a purported domestication of modern humans," he said."In an elegant study [the team] exploited the links between BAZ1B and facial and behavioral changes in Williams-Beuren, and detail how this gene mediates the induction and migration of specialized cells at the core of facial development.
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